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Born in Santa Ana, Orange County, California to Dick and Donna Pfeiffer, she has three siblings, an older brother and two younger sisters.
In 1981, she married actor Peter Horton[?], but they later divorced. In 1993, Pfeiffer adopted a girl; later that year, she married producer David E. Kelley, the creator of the Chicago Hope and Ally McBeal television series; a son was born in 1994.
Her first starring role was in the 1982 musical Grease 2[?]. Her most recent work includes roles in the movies Sinbad: Legend of the Seven Seas[?], What Lies Beneath[?], White Oleander[?], and I Am Sam. As a singer, she became most widely known with her role in The Fabulous Baker Boys[?].
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